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Withdrawal of digoxin from patients with chronic heart failure treated withangiotensin-converting enzyme inhibitors. During the donor T cell response to the recipient‘s minor andmajor tissue-specific MHC antigens, which occurs during every HSCT situation, Tregsimmediately begin to attack not only responding T cells, but also antigen-presenting DC.Because the Treg can secrete massive amounts of adenosine through the conversion ofintercellular ATP (released from dead cells), it has the ability to activate its own PKApathway in an autocrine fashion, which allows them to produce more intracellular cAMP.This Treg cAMP is used to paralyze responding T cells and DC, but it gets depleted becausenormally Tregs compose 1% of the T cell compartment and must inject cAMP into multipleresponding T cells. Anal transition zone in the surgical management ofulcerative colitis.